Tor Lab Publications

194. Li, Y.; Fin, A.; Rovira, A. R.; Su, Y.; Dippel, A. B.; Valderrama, J. A.; Riestra, A.; Nizet, V.; Hammond, M. C.; Tor, Y. "Tuning the Innate Immune Response to Cyclic Dinucleotides Using Atomic Mutagenesis" ChemBioChem 2020, in press. [Article Link]

193. Didier, P.; Kuchlyan, J.; Martinez-Fernandez, L.; Gosset, P.; Leonard, J.; Tor, Y.; Improta, R.; Mely, Y. "Deciphering the pH-dependence of ground- and excited-state equilibria of thienoguanine" PhysChemChemPhys 2020, in press. [Article Link]

192. Li, Y.; Ludford III, P. T.; Fin, A.; Rovira, A. R.; Tor, Y. "Enzymatic Synthesis and Applications of Fluorescent Cyclic Dinucleotides" Chem. Eur. J. 2020, in press. [Article Link]

191. Nobis, D.; Fisher, R. S.; Simmermacher, M.; Hopkins, P. A.; Tor, Y.; Jones, A. C.; Magennis, S. W. "Single-Molecule Detection of a Fluorescent Nucleobase Analogue via Multiphoton Excitation" J. Phys. Chem. Lett. 2019, 10, 5008-5012. [Article Link]

190. Feldmann, J.; Li, Y.; Tor, Y. "Emissive Synthetic Cofactors: A Highly Responsive NAD+ Analogue Reveals Biomolecular Recognition Features" Chem. Eur. J. 2019, Accepted. [Article Link]

189. Ludford, P. T.; Rovira, A. R.; Fin, A.; Tor, Y. "Fluorescing Isofunctional Ribonucleosides: Assessing Adenosine Deaminase Activity and Inhibition" ChemBioChem 2019, 20, 718-726. [Article Link]

188. Naini, S. M. A.; Yanicostas, C.; Hassan-Abdi, R.; Blondeel, S.; Bennis, M.; Weiss, R. J.; Tor, Y.; Esko, J. D.; Soussi-Yanicostas, N. "Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy" Translational Neurodegeneration 2018, 7:6. [Article Link]

187. Sholokh, M.; Sharma, R.; Grytsyk, N.; Zaghzi, L.; Postupalenko, V. Y.; Dziuba, D.; Barthes, N. P. F.; Michel, B. Y.; Boudier, C.; Zaporozhets, O. A.; Tor, Y.; Burger, A.; Mely, Y. "Environmentally Sensitive Fluorescent Nucleoside Analogues for Surveying Dynamic Interconversions of Nucleic Acid Structures" Chem. Eur. J. 2018, 24, 13850-13861. [Article Link]

186. Ejlersen, M.; Lou, C.; Sanghvi, Y. S.; Tor Y.; Wengel, J. "Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions" Chem. Commun. 2018, 54, 8003-8006. [Article Link]

185. Hallé, F; Fin, A; Rovira, A. R.; Tor, Y. "Emissive synthetic cofactors: enzymatic interconversions of tzA analogues of ATP, NAD+, NADH, NADP+ and NADPH" Angew. Chem. Int. Ed. 2017, 57, 1087-1090. [Article Link]

184. Hadidi, K; Wexselblatt, E.; Esko, J. D.; Tor, Y. "Cellular uptake of modified aminoglycosides" J. Antibiot. 2018, 71, 142-145. [Article Link]

183. Rovira, A. R.; Fin, A.; Tor, Y. "Emissive synthetic cofactors: An isomorphic, isofunctional and re-sponsive NAD+ analogue" J. Am. Chem. Soc. 2017, 139, 15556–15559. [Article Link]

182. Rovira, A. R.; Tor, Y. "Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides" J. Antibiot. 2017, 71, 342–344. [Article Link]

181. Yaakov, N.; Chaikin, Y.; Wexselblatt, E.; Tor, Y.; Vaskevich, A.; Rubinstein, I. "Application of Surface Click Reactions to Localized Surface Plasmon Resonance (LSPR) Biosensing" Chem. Eur. J. 2017, 23, 10148-10155. [Article Link]

180. Weiss, R. J.; Esko, J.; Tor, Y. "Targeting Heparin– and Heparan Sulfate–Protein Interactions" Org. Biomol. Chem. 2017, 15, 5656-5668. [Article Link]

179. Tor, Y. "Catalyst: On Organic Systems Chemistry and Origins Research" Chem 2017, 2, 448-450. [Article Link]

178. Rovira, A. R.; Fin, A.; Tor, Y. "Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates" Chem. Sci. 2017, 8, 2983-2993. [Article Link]

177. Hopkins, P. A.; McCoy, L. S.; Tor, Y. "Enzymatic incorporation and utilization of an emissive 6-azauridine" Org. Biomol. Chem. 2017, 15, 684-690. [Article Link]

176. Li, Y.; Fin, A.; McCoy, L. S.; Tor, Y. "Polymerase-Mediated Site-Specific Incorporation of a Synthetic Fluorescent Isomorphic G Surrogate into RNA" Angew. Chem. Int. Ed. 2017, 56, 1303-1307. [Article Link]

175. Kilin, V.; Gavvala, K.; Barthes, N. P. F.; Michel, B. Y.; Shin, D.; Boudier, C.; Mauffret, O.; Yashchuk, V.; Mousli, M.; Ruff, M.; Granger, F.; Eiler, S.; Bronner, C.; Tor, Y.; Burger, A.; Mély, Y. "Dynamics of Methylated Cytosine Flipping by UHRF1" J. Am. Chem. Soc. 2017, 139, 2520-2528. [Article Link]

174. Sganappa, A.; Wexselblatt, E.; Bellucci, M. C.; Esko, J. D.; Tedeschi, G.; Tor, Y.; Volonterio, A. "Dendrimeric Guanidinoneomycin for Cellular Delivery of Bio-macromolecules" Chembiochem 2017, 18, 119-125. [Article Link]

173. Sholokh M.; Improta, R; Mori, M.; Sharma, R.; Kenfack, C.; Shin, D.; Voltz, K.; Stote, R. H.; Zaporozhets, O. A.; Botta, M; Tor, Y.; Mély, Y. "Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels" Angew. Chem. Int. Ed. 2016, 55, 7974-7978. [Article Link]

172. Sganappa, A.; Bellucci, M. C.; Nizet, V.; Tor, Y.; Volonterio, A. "Multicomponent Domino Synthesis and Antibacterial Activity of Neomycin–Sugar Conjugates" Synthesis 2016, 28, 4443-4450. [Article Link]

171. Kong, B.; Joshi, T.; Belousoff, M. J.; Tor, Y.; Graham, B.; Spiccia L. "Neomycin B-cyclen conjugates and their Zn(II) complexes as RNA-binding agents" J. Inorg. Biochem. 2016, 162, 334-342. [Article Link]

170. Hamill, K. M.; Wexselblatt, E.; Tong, W.; Esko, J.; Tor, Y. "Delivery of an Active Lysosomal Enzyme Using GNeosomes" J. Mater. Chem. B 2016, 4, 5794-5797. [Article Link]

169. Vranken, C.; Fin, A.; Tufar, P.; Hofkens, J.; Burkart, M.; Tor, Y. "Chemoenzymatic Synthesis and Utilization of a SAM Analog with an Isomorphic Nucleobase" Org. Biomol. Chem. 2016, 14, 6189-6192. [Article Link]

168. Freeman, N. S.; Moore, C. E.; Wilhelmsson, L. M.; Tor, Y. "Chromophoric Nucleoside Analogs: Synthesis and Characterization of 6-Aminouracil-Based Nucleodyes" J. Org. Chem. 2016, 81, 4530-4539 [Article Link]

167. Hamill, K. M.; McCoy, L. S.; Wexselblatt, E.; Esko, J. D.; Tor, Y. "Polymyxins facilitate entry into mammalian cells" Chem. Sci. 2016, 7, 5059-5068. [Article Link]

166. Fin, A.; Rovira, A. R.; Hopkins, P. A.; Tor. Y. Emissive 5-Substituted Uridine Analogues. In Modified Nucleic Acids, 1 ed.; Tor, Y., Nakatani, K., Eds.; Springer: 2016; Vol. 31, pp 1-26.

165. Rovira, A. R.; Fin, A.; Tor, Y. "Chemical Mutagenesis of an Emissive RNA Alphabet" J. Am. Chem. Soc. 2015, 137, 14602-14605. [Article Link]

164. Weiss, R. J.; Gordts, P. L. S. M.; Le, D.; Xu, D.; Esko, J. D.; Tor, Y. "Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions" Chem. Sci. 2015, 6, 5984-5993. [Article Link]

163. Mizrahi, R. A.; Shin, D.; Sinkeldam, R. W.; Phelps, K. J.; Fin, A.; Tantillo, D. J.; Tor, Y; Beal, P. A. "A Fluorescent Adenosine Analogue as a Substrate for an A-to-I RNA Editing Enzyme" Angew. Chem. Int. Ed. 2015, 54, 8713-8716. [Article Link]

162. Wexselblatt, E.; Esko, J. D.; Tor, Y. "GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery" ACS Nano 2015, 9, 3961-3968. [Article Link]

161. Sholokh, M.; Sharma, R.; Shin, D.; Tor, Y.; Mely, Y. "Conquering 2-Aminopurine's Deficiencies: Highly Emissive Isomor-phic Guanosine Surrogate Faithfully Monitors Guanosine Conformation and Dynamics in DNA" J. Am. Chem. Soc. 2015, 137, 3185-3188. [Article Link]

160. Tor, Y.; Siegel, J. S. "50 years of physical organic chemistry" J. Phys. Org. Chem 2015, 28, 172. [Article Link]

159. Shin, D.; Lonn, P.; Dowdy, S.; Tor, Y. "Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates" Chem. Comm. 2015, 51, 1662-1665. [Article Link]

158. Rios, A. C.; Yu, H. T.; Tor, Y. "Hydrolytic fitness of N-glycosyl bonds: comparing the deglycosylation kinetics of modified, alternative, and native nucleosides" J. Phys. Org. Chem. 2015, 28, 173-180. [Article Link]

157. Hopkins, P. A.; Sinkeldam, R. W.; Tor, Y. "Visibly Emissive and Responsive Extended 6-Aza-Uridines" Org. Lett. 2014, 16, 5290-5293. [Article Link]

156. McCoy, L. S.; Shin, D.; Tor, Y. "Isomorphic emissive GTP surrogate facilitates initiation and elongation of in vitro transcription reactions" J. Am. Chem. Soc. 2014, 136, 15176-15184. [Article Link]

155. Fair, R.; Tor, Y. "Antibiotics and Bacterial Resistance in the 21st Century" Perspect. Medicin. Chem. 2014, 6, 25-64. [Article Link]

154. Fair, R. J.; McCoy, L. S.; Hensler, M. E.; Aguilar, B.; Nizet, V.; Tor, Y. "Singly Modified Amikacin and Tobramycin Derivatives Show Increased rRNA A-Site Binding and Higher Potency against Resistant Bacteria" ChemMedChem 2014, 9, 2164-2171. [Article Link]

153. Wexselblatt, E.; Esko, J. D.; Tor, Y. "On Guanidinium and Cellular Uptake" J. Org. Chem. 2014, 79, 6766-6774. [Article Link]

152. Muller, U. F.; Tor, Y. "Citric Acid and the RNA World" Angew. Chem. Int. Ed. 2014, 53, 5245-5247. [Article Link]

151. Lane, R. S. K.; Jones, R.; Sinkeldam, R. W.; Tor, Y.; Magennis, S. W. "Two-Photon-Induced Fluorescence of Isomorphic Nucleobase Analogs" ChemPhysChem 2014, 15, 867-871. [Article Link]

150. Inoue, M.; Wexselblatt, E.; Esko, J. D.; Tor, Y. "Macromolecular Uptake of Alkyl-Chain-Modified Guanidinoglycoside Molecular Transporters" ChemBioChem 2014, 15, 676-680. [Article Link]

149. Sinkeldam, R. W.; McCoy, L. S.; Shin, D.; Tor, Y. "Enzymatic Interconversion of Isomorphic Fluorescent Nucleosides: Adenosine Deaminase Transforms an Adenosine Analogue into an Inosine Analogue" Angew. Chem. Int. Ed. 2013, 52, 14026-14030. [Article Link]

148. McCoy, L. S.; Roberts, K. D.; Nation, R. L.; Thompson, P. E.; Velkov, T.; Li, J.; Tor, Y. "Polymyxins and Analogues Bind to Ribosomal RNA and Interfere with Eukaryotic Translation in Vitro" ChemBioChem 2013, 14, 2083-2086. [Article Link]

147. Noe, M.; Sinkeldam, R. W.; Tor, Y. "Oligodeoxynucleotides Containing Multiple Thiophene-modified Isomorphic Fluorescent Nucleosides" J. Org. Chem. 2013, 78, 8123-8128. [Article Link]

146. Liu, W.; Shin, D.; Tor, Y.; Cooperman, B. S. "Monitoring Translation with Modified mRNAs Strategically Labeled with Isomorphic Fluorescent Guanosine Mimetics" ACS Chem. Biol. 2013, 8, 2017-2023. [Article Link]

145. Rios, A. C.; Tor, Y. "On the Origin of the Canonical Nucleobases: An Assessment of Selection Pressures across Chemical and Early Biological Evolution" Isr. J. Chem. 2013, 53, 469-483. [Article Link]

144. Inoue, M.; Tong, W.; Esko, J. D.; Tor, Y. "Aggregation-Mediated Macromolecular Uptake by a Molecular Transporter" ACS Chem. Biol. 2013, 8, 1383-1388 [Article Link]

143. Frolov, L.; Dix, A.; Tor, Y.; Tesler, A. B.; Chaikin, Y.; Vaskevich, A.; Rubinstein, I. "Direct Observation of Aminoglycoside-RNA Binding by Localized Surface Plasmon Resonance Spectroscopy. Anal. Chem. 2013, 85, 2200-2207. [Article Link]

142. Rios, A. C.; Tor, Y. "Refining the Genetic Alphabet: A Late-Period Selection Pressure?" Astrobiology 2012, 12, 884-891. [Article Link]

141. Sinkeldam, R. W.; Hopkins, P. A.; Tor, Y. "Modified 6-Aza Uridines: Highly Emissive pH-Sensitive Fluorescent Nucleosides" ChemPhysChem 2012, 13, 3350-3356. [Article Link]

140. Noe, M. S.; Rios, A. C.; Tor, Y. "Design, Synthesis, and Spectroscopic Properties of Extended and Fused Pyrrolo-dC and Pyrrolo-C Analogs" Org. Lett. 2012, 14, 3150-3153. [Article Link]

139. Fair, R. J.; Hensler, M. E.; Thienphrapa, W.; Dam, Q. N.; Nizet, V.; Tor, Y. "Selectively Guanidinylated Aminoglycosides as Antibiotics" ChemMedChem 2012, 7, 1237-1244. [Article Link]

138. Wanunu, M.; Bhattacharya, S.; Xie, Y.; Tor, Y.; Aksimentiev, A.; Drndic, M. "Nanopore Analysis of Individual RNA/Antiobiotic Complexes" ACS Nano, 2011, 5, 9345-9353. [Article Link]

137. Shin, D.; Sinkeldam, R. W.; Tor, Y. "Emissive RNA Alphabet" J. Am. Chem. Soc. 2011, 133, 14912-14915. [Article Link]

136. Sinkeldam, R. W.; Marcus, P.; Uchenik, D.; Tor, Y. "Multisensing Emissive Pyrimidine" ChemPhysChem 2011, 12, 2260-2265. [Article Link]

135. Shin, D.; Tor, Y. "Bifacial Nucleoside as a Surrogate for Both T and A in Duplex DNA" J. Am. Chem. Soc. 2011, 133, 6926-6929. [Article Link]

134. Sinkeldam, R. W.; Wheat, A. J.; Boyaci, H.; Tor, Y. "Emissive Nucleosides as Molecular Rotors" ChemPhysChem 2010, 12, 567-570. [Article Link]

133. Xie, Y.; Maxson, T.; Tor, Y. "Fluorescent Nucleoside Analogue Displays Enhanced Emission upon Pairing with Guanine" Org. Biomol. Chem. 2010, 8, 5053-5055. [Article Link]

132. Dix, A. V.; Fischer, L.; Sarrazin, S.; Redgate, C. P. H.; Esko, J. D.; Tor, Y. "Cooperative, Heparan Sulfate-Dependent Cellular Uptake of Dimeric Guanidinoglycosides" ChemBioChem 2010, 11, 2302-2310. [Article Link]

131. Xie, Y.; Maxson, T.; Tor, Y. "Fluorescent Ribonucleoside as a FRET Acceptor fo Tryptophan" J. Am. Chem. Soc. 2010, 132, 11896-11897. [Article Link]

130. Xie, Y.; Dix, A. V.; Tor, Y. "Antibiotic Selectivity for Prokaryotic vs. Eukaryotic Decoding Sites" Chem. Comm. 2010, 46, 5542-5544. [Article Link]

129. Sinkeldam, R. W.; Greco, N.; Tor, Y. "Fluorescent Analogs of Biomolecular Building Blocks: Design, Properties, and Applications" Chem. Rev. 2010, 110, 2579-2619. [Article Link]

128. Sarrazin, S.; Wilson, B.; Sly, W. S.; Tor, Y.; Esko, J. D. "Guanidinylated Neomycin Mediates Heparan Sulfate-dependent Transport of Active Enzymes to Lysosomes" Mol. Ther. 2010, 18, 1268-1274. [Article Link]

127. Xie, Y.; Dix, A. V.; Tor, Y. "FRET Enabled Real Time Detection of RNA-Small Molecule Binding" J. Am. Chem. Soc. 2009, 131, 17605-17614. [Article Link]

126. Rios, A. C.; Tor, Y. "Model Systems: how chemical biologists study RNA" Curr. Opin. Chem. Biol. 2009, 13, 660-668. [Article Link]

125. Greco, N. J.; Sinkeldam, R. W.; Tor, Y. "An Emmisive C Analogue Distinguishes between G, 8-oxoG, and T" Org. Lett. 2009, 11, 1115-1118. [Article Link]

124. Belousoff, M. J.; Ung, P.; Forsyth, C. M.; Tor, Y.; Spiccia, L.; Graham, B. "New Macrocyclic Terbium(III) Complex for Use in RNA Footprinting Experiments" J. Am. Chem. Soc. 2009, 131, 1106-1114. [Article Link]

123. Belousoff, M. J.; Gasser, G.; Graham, B.; Tor, Y.; Spiccia, L. "Binding of HIV-1 TAR mRNA to a peptide nucleic acid oligomer and its conjugates with metal-ion-binding multidentate ligands" J. Biol. Inorg. Chem. 2009, 14, 287-300. [Article Link]

122. Tor, Y. "Exploring RNA-ligand interactions" Pure Appl. Chem. 2009, 81, 263-272. [Article Link]

121. Srivatsan, S. G.; Tor, Y. "Enzymatic Incorporation of Emissive Pyrimidine Ribonucleotides" Chem. Asian J. 2009, 4, 419-427. [Article Link]

120. Belousoff, M. J.; Graham, B.; Spiccia, L.; Tor, Y. "Cleavage of RNA oligonucleotides by aminoglycosides" Org. Biomol. Chem. 2009, 7, 30-33. [Article Link]

119. Schuksz,M; Fuster, M. M.; Brown, J. R.; Crawford, B. E.; Ditto, D. P.; Lawrence, R.; Glass, C. A.; Wang, L.; Tor, Y.; Esko, J. D. "Surfen, a small molecule antagonist of heparan sulfate" Proc. Natl. Acad. Sci. 2008, 105, 13075-13080. [Article Link]

118. Srivatsan, S. G.; Greco, N. J.; Tor, Y. "A Highly Emissive Fluorescent Nucleoside that Signals the Activity of Toxic Ribosome-Inactivating Proteins" Angew. Chem. Int. Ed. 2008, 47, 6661-6665. [Article Link]

117. Srivatsan, S. G.; Tor, Y. "A highly fluorescent nucleoside analog based on thieno[3,4-d]pyrimidine senses mismatched pairing" Org. Biomol. Chem. 2008, 6, 1334-1338. [Article Link]

116. Sinkeldam, R. W.; Greco, N. J.; Tor, Y. "Polarity of Major Grooves Explored by Using an Isosteric Emissive Nucleoside" ChemBioChem, 2008, 9, 706-709. [Article Link]

115. Staple, D. W.; Venditti, V.; Niccolai, N.; Elson-Schwab, L.; Tor, Y.; Butcher, S. E. "Guanidinoneomycin B recognition of an HIV-1 RNA helix" ChemBioChem, 2008, 9, 93-102. [Article Link]

114. Glazer, E. C.; Magde, D.; Tor, Y. "Ruthenium Complexes that Break the Rules: Structural Features Controlling Dual Emission" J. Am. Chem. Soc. 2007, 129, 8544-8551. [Article Link]

113. Srivatsan, S. G.; Tor, Y. "Synthesis and enzymatic incorporation of a fluorescent pyrimidine ribonucleotide" Nature Protocols, 2007, 2, 1547-1555. [Article Link]

112. Barbieri, C. M.; Kaul, M.; Bozza-Hingos, M.; Zhao, F.; Tor, Y.; Hermann, T.; Pilch, D. S. "Defining the Molecular Forces That Determine the Impact of Neomycin on Bacterial Protein Synthesis: Importance of the 2'-Amino Functionality" Antimicrob. Agent Chemother. 2007, 51, 1760-1769. [Article Link]

111. Tor, Y. "Fluorescent Nucleoside Analogues: Synthesis, Properties and Applications" (Editorial) Tetrahedron, 2007, 63, 3425-3426. [Article Link]

110. Elson-Schwab, L.; Garner, O. B.; Schuksz, M.; Crawford, B. E.; Esko, J.; Tor, Y. "Guanidinylated Neomycin Delivers Large, Bioactive Cargo into Cells through a Heparan Sulfate-dependent Pathway" J. Biol. Chem. 2007, 282, 13585-13591. [Article Link]

109. Tor, Y.; Del Valle, S.; Jaramillo, D.; Srivatsan, S. G.; Rios, A.; Weizman, H. "Designing New Isomorphic Fluorescent Nucleobase Analogues: The Thieno[3,2-d]pyrimidine Core" Tetrahedron 2007, 63, 3608-3614. [Article Link]

108. Srivatsan, S. G.; Tor, Y. "Using an Emissive Uridine Analogue for Assembling Fluorescent HIV-1 TAR Constructs" Tetrahedron 2007, 63, 3601-3607. [Article Link]

107. Greco, N.; Tor, Y. "Furan Decorated Nucleoside Analogues as Fluorescent Probes: Synthesis, Photo-physical Evaluation, and Site-Specific Incorporation" Tetrahedron 2007, 63, 3515-3527. [Article Link]

106. Tam, V.; Kwong, D.; Tor, Y. "Fluorescent HIV-1 Dimerization Initiation Site: Design, Properties, and Use for Ligand Discovery" J. Am. Chem. Soc. 2007, 129, 3257-3266. [Article Link]

105. Greco, N.; Tor, Y. "Synthesis and site-specific incorporation of a simple fluorescent pyrimidine" Nature Protocols 2007, 2, 305-316. [Article Link]

104. Srivatsan, S. G.; Tor, Y. "Fluorescent Pyrimidine Ribonucleotide: Synthesis, Enzymatic Incorporation, and Utilization" J. Am. Chem. Soc. 2007, 129, 2044-2053. [Article Link]

103. Blount, K.; Tor, Y. "A Tale of Two Targets: Differential RNA Selectivity of Nucleobase-Aminoglycoside Conjugates" ChemBioChem 2006, 7, 1612-1621. [Article Link]

102. Yu, D.-H.; MacDonald, J.; Josephs, S.; Liu, Q.; Nguy, B.; Tor, Y.; Wong-Staal, F.; Li. Q. X. "MDDD, a 4,9-diazapyrenium derivative is selectively toxic to glioma cells by inducing growth arrest at G0/G1 independently of p53" Invest. New Drugs 2006, 24, 489-498. [Article Link]

101. Yang, G.; Trylska, H.; Tor, Y.; McCammon, J. A. "Binding of Aminoglycosidic Antibiotics to the Oligonucleotide A-site Model and 30S Ribosomal Subunit: Poisson-Boltzmann Model, Thermal Denaturation and Fluorescence Studies" J. Med. Chem. 2006, 49,5478-5490. [Article Link]

100. Jaramillo, D.; Wheate, N. J.; Raph, S. F.; Howard, W. A.; Tor, H.; Aldrich-Wright, J. R. "Polyamide Platinum Anti-Cancer Complexes Designed to Target Specific DNA Sequences" Inorg. Chem. 2006, 45, 6004-6013. [Article Link]

99. Talley, T. T.; Yalda, S.; Ho, K.-Y.; Sati, F.; Tor, Y.; Kem, W.; Taylor, P. "Spectroscopic Analysis of Benzylidene Anabaseine Complexes with Acetylcholine Binding Proteins as Models for Ligand-Nicotinic Receptor Interactions" Biochemistry 2006, 45, 8894-8902. [Article Link]

98. Tam, V. K.; Liu, Q.; Tor, Y. "Extended ethidium bromide analogue as a triple helix intercalator: synthesis, photophysical properties and nucleic acids binding" Chem. Commun. 2006, 2684-2686. [Article Link]

97. Nemat-Nasser, S.; Zamani, S.; Tor, Y. "Effect of Solvents on the Chemical and Physical Properties of Ionic Polymer Metal Composites" J. Appl. Phys. 2006, 99, 104902/1-104902/17. [Article Link]

96. Greco, N. J.; Hysell, M.; Goldenberg, J. R.; Rheingold, A. L.; Tor, Y. "Alkyne-containing chelating ligands: synthesis, properties and metal coordination of 1,2-di(quinolin-8-yl)ethyne" Dalton Trans. 2006, 19, 2288-2290. [Article Link]

95. Jouvenot, D.; Glazer, E. C.; Tor, Y. "Photodimerizable Ditopic Ligand" Org. Lett. 2006, 8, 1987-1990. [Article Link]

94. Tor, Y. "The ribosomal A-site as an inspiration for the design of RNA binders" Biochimie 2006, 88, 1045-1051. [Article Link]

93. Zhao, F.; Zhao, Q.; Blount, K.; Han, Q.; Tor, Y.; Hermann, T. "Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative" Angew. Chem. Int. Ed. 2005, 44, 5329-5334. [Article Link]

92. Hysell, M.; Siegel, J. S.; Tor, Y. "Synthesis and Stability of Exocyclic Triazine Nucleosides" Org. Biomol. Chem. 2005, 3, 2946-2952. [Article Link]

91. Greco, N.; Tor, Y. "Simple Fluorescent Pyrimidine Analogues Detect the Presence of DNA Abasic Sites" J. Am. Chem. Soc. 2005, 127, 10784-10785. [Article Link]

90. Blount, K. F.; Zhao, F.; Hermann, T.; Tor, Y. "Conformational Constraint as a Means for Understanding RNA-Aminoglycoside Specificity" J. Am. Chem. Soc. 2005, 127, 9818-9829. [Article Link]

89. Siegel, J. S.; Tor, Y. "Genetic Alphabetic Order: What came before A?" Org. Biomol. Chem. 2005, 3, 1591-1592. [Article Link]

88. Glazer, E. C.; Belyea, B.; Tor, Y. "A Simple Synthesis of Isotopically Pure 2,2'-Bipyridyl-d8" Inorg. Chem. Commun. 2005, 8, 517-519. [Article Link]

87. Glazer, E. C.; Magde, D.; Tor, Y. "Dual Emission from a Family of Conjugated Dinuclear RuII Complexes. J. Am. Chem. Soc. 2005, 127(12), 4190-4192. [Article Link]

86. Hermann, T.; Tor, Y. "RNA as a Target for Small-molecule Therapeutics" Exper. Opin. on Therapeutic Patents 2005, 15, 49-62. [Article Link]

85. Boer, J.; Blount, K. F.; Luedtke, N. W.; Elson-Schwab, L.; Tor, Y. "RNA-selective Modification by a Pt(II) Complex Conjugated to Amino- and Guanidino-glycosides" Angew. Chem. Int. Ed. 2005, 44, 927-932. [Article Link]

84. Luedtke, N. W.; Liu, Q.; Tor, Y. "On the Electronic Structure of Ethidium" Chem. Eur. J. 2005, 11, 495-508. [Article Link]

83. Jaramillo, D.; Liu, Q.; Aldrich-Wright, J.; Tor, Y. "Synthesis of N-methylpyrrole and N-methylimidazole Amino Acids Suitable for Solid-Phase Synthesis" J. Org. Chem. 2004, 69, 8151-8153. [Article Link]

82. Tor, Y. "Advancing RNA as a Drug Target" MedChem News (The Pharmaceutical Society of Japan) 2004, 14(3), 6-13.

81. Aldrich-Wright, J.; Brodie, C.; Glazer, E. C.; Luedtke, N. W.; Elson-Schwab, L.; Tor, Y. "Symmetrical Dinuclear Complexes with High DNA Affinity based on [Ru(dpq)2(phen)]+2" Chem. Comm. 2004, 1018-1019. [Article Link]

80. Luedtke, N. W.; Liu, Q.; Tor, Y. "Synthesis, Photophysical Properties, and Nucleic Acid Binding of Phenanthridinium Derivatives Based on Ethidium" Bioorg. Med. Chem. 2003, 11, 5235-5247. [Article Link]

79. Luedtke, N. W.; Carmichael, P.; Tor, Y. "Cellular Uptake of Aminoglycosides, Guanidinoglycosides and Poly-arginine" J. Am. Chem. Soc. 2003, 125, 12374-12375. [Article Link]

78. Luedtke, N. W.; Hwang, J. S.; Nava, E.; Gut, D.; Kol, M.; Tor, Y. "The DNA and RNA Specificity of Eilatin Ru(II) Complexes as Compared to Eilatin and Ethidium Bromide" Nucleic Acid Res. 2003, 31, 5732-5740. [Article Link]

77. Blount, K. F.; Tor, Y. "Using Pyrene-labeled HIV-1 Tar to Measure RNA-Small Molecule Binding" Nucleic Acid Res. 2003, 31, 5490-5500. [Article Link]

76. Tor, Y. "Targeting RNA with Small Molecules" ChemBioChem 2003, 4, 998-1007. [Article Link]

75. Luedtke, N. W.; Liu, Q.; Tor, Y. "RNA-Ligand Interactions: Affinity and Specificity of Aminoglycoside Dimers and Acridine Conjugates to the HIV-1 Rev Response Element" Biochemistry 2003, 42, 11391-11403. [Article Link]

74. Tor, Y. "Metal-containing Oligomers, Dendrimers and Biopolymers" Comptes rendus Chimie 2003, 6, 755-766. [Article Link]

73. Tor, Y. "RNA-Ligand Interactions" (Editorial) Biopolymers 2003, 70, 1-3. [Article Link]

72. Luedtke, N.; Tor, Y. "Fluorescence-based Methods for Evaluating the RNA Affinity and Specificity of HIV-1 Rev-RRE Inhibitors" Biopolymers 2003, 70, 103-119. [Article Link]

71. Weizman, H.; Tor, Y. "RNA-Aminoglycoside Interactions" in Carbohydrate-based Drug Discovery; C.-H. Wong, C.-H. Ed.; Wiley-VCH, 2003, vol. 2, pp. 661-683. [Article Link]

70. Liu, Q.; Tor, Y. "Simple Conversion of Aromatic Amines into Azides" Org. Lett. 2003, 5, 2571-2572. [Article Link]

69. Fineberg, K.; Fineberg, T.; Graessmann, A.; Luedtke, N. W.; Tor, Y.; Lixin, D.; Jans, D. A.; Loyter, A. "Inhibition of Nuclear Import Mediated by the Rev-Arginine Rich Motif by RNA Molecules" Biochemistry 2003, 42, 2625-2633. [Article Link]

68. Luedtke, N. W.; Tor, Y. "Targeting HIV RNA with Small Molecules" in Small Molecule DNA and RNA Binders: From Synthesis to Nucleic Acid Complexes; Demeunynck, M.; Bailly, C; Wilson, W. D. Ed.; Wiley-VCH, 2003, pp. 18-40. [Chapter Link]

67. Glazer, E. C.; Tor, Y. "Ru(II)-Complexes of "Large Surface" Ligands" Angew. Chem. Int. Ed. 2002, 41,4022-4026. [Article Link]

66. Hurley, D. J.; Seaman, S. E.; Mazura, J. C.; Tor, Y. "Fluorescent 1,10-Phenanthroline-Containing Oligonucleotides Distinguish Between Perfect and Mismatched Base Pairing" Org. Lett. 2002, 4, 2305-2308. [Article Link]

65. Luedtke, N. W.; Hwang, J. S.; Glazer, E. C.; Gut, D.; Kol, M.; Tor, Y. "Eilatin Ru(II) Complexes Display Anti-HIV Activity and Enantiomeric Diversity in the Binding of RNA" ChemBioChem 2002, 3, 766-771. [Article Link]

64. Hurley, D. J.; Tor, Y. "Donor-Acceptor Interactions in Systematically Modified Ru(II)-Os(II) Oligonucleotides" J. Am. Chem. Soc. 2002, 124, 13231-13241. [Article Link]

63. Hurley, D. J.; Tor, Y. "Ru(II) and Os(II) Nucleosides and Oligonucleotides: Synthesis and Properties" J. Am. Chem. Soc. 2002, 124, 3759-3762. [Article Link]

62. Tor, Y. "Coordination Compounds as Synthetic Building Blocks" Synlett 2002, 1043-1054. [Article Link]

61. Weizman, H.; Tor, Y. "Redox Active Metal-Containing Nucleotides: Synthesis, Tunability and Enzymatic Incorporation into DNA" J. Am. Chem. Soc. 2002, 124, 1568-1569. [Article Link]

60. Hurley, D. J.; Tor, Y. "Lowering the Symmetry of Difunctionalized Coordination Compounds via Nucleophilic Aromatic Substitutions" Tetrahedron Letters 2001, 42, 7217-7220. [Article Link]

59. Kirk, S. R.; Luedtke, N. W.; Tor, Y. "2-Aminopurine as a Real-Time Probe of Enzymatic Cleavage and Inhibition of Hammerhead Ribozymes" Bioorg. Med. Chem. 2001, 9, 2295-2301. [Article Link]

58. Weizman, H.; Tor, Y. "2,2'-Bipyridine Ligandoside: A Novel Building Block for Modifying DNA with Intra-Duplex Metal Complexes" J. Am. Chem. Soc. 2001, 123, 3375-3376. [Article Link]

57. Joshi, H. S.; Tor, Y. "Metal-Containing DNA Hairpins as Hybridization Probes" Chem. Commun. 2001, 549-550. [Article Link]

56. Weizman, H.; Tor, Y. "Oligo-ligandosides: A DNA Mimetic Approach to Helicate Formation" Chem. Commun. 2001,453-454. [Article Link]

55. Liu, Q.; Luedtke, N. W.; Tor, Y. "A Simple Conversion of Amines into Monosubstituted Ureas in Organic and Aqueous Solvents" Tetrahedron Lett. 2001, 42, 1445-1447. [Article Link]

54. Michael, K.; Tor, Y. "Modifying Aminoglycoside Antibiotics" in RNA-Binding Antibiotics; Scrodeder, R.: Wallis, M. J. Ed.; Landes Bioscience, Austin, 2001, pp. 130-145.

53. Baker, T. J.; Luedtke, N. W.; Tor, Y.; Goodman, M. "Synthesis and Anti-HIV Activity of Gunidinoglycosides" J. Org. Chem.2000, 65, 9054-9058. [Article Link]

52. Luedtke, N. W.; Baker, T. J.; Goodman, M.; Tor. Y. "Guanidinoglycosides: A Novel Family of RNA Ligands" J. Am. Chem. Soc.2000, 122, 12035-12036. [Article Link]

51. Friedler, A.; Friedler, D.; Luedtke, N. W.; Tor, Y.; Loyter, A.; Gilon, C. "Development of a Functional Backbone Cyclic Mimetic of the HIV-1 Tat Arginine Rich Motif" J. Biol. Chem. 2000, 23783-23789. [Article Link]

50. Luedtke, N. W.; Tor, Y. "A Novel Solid-Phase Assembly for Identifying Potent and Selective RNA Ligands" Angew. Chem. Int. Ed. 2000, 39, 1788-1790. [Article Link]

49. Kirk, S. R.; Luedtke, N. W.; Tor, Y. "Neomycin-Acridine Conjugate: A Potent Inhibitor of Rev-RRE Binding" J. Am. Chem. Soc. 2000, 122, 980-981. [Article Link]

48. Joshi, H. S.; Jamshidi, R.; Tor, Y. "Conjugated 1,10-Phenanthrolines as Tunable Fluorophores" Angew. Chem. Int. Ed. 1999, 39, 2721-2725. [Article Link]

47. Hurley, D.J.; Roppe, J. R.; Tor, Y. "Coordination Compounds as Building Blocks: Simple Synthesis of Ru(II)-Containing Amino Acids and Peptides" Chem. Commun. 1999, 993-994. [Article Link]

46. Tor, Y. "RNA and the Small Molecule World" Angew. Chem. Int. Ed. 1999, 38, 1579-1582. [Article Link]

45. Kirk, S. R.; Tor, Y. "tRNAPhe Binds Aminoglycoside Antibiotics" Bioorg. Med. Chem. 1999, 7, 1979-1991. [Article Link]

44. Michael, K.; Wang, H.; Tor, Y. "Enhanced RNA Binding of Dimerized Aminoglycosides" Bioorg. Med. Chem. 1999, 7, 1361-1371. [Article Link]

43. Wang, H.; Tor, Y. "Tobramycin-EDTA Conjugate: A Noninnocent Affinity-Cleaving Reagent" Bioorg. Med. Chem. Lett. 1998, 8, 3665-3670. [Article Link]

42. Tor, Y.; Hermann, T.; Westhof, E. "Deciphering RNA Recognition: Aminoglycoside Binding to the Hammerhead Ribozyme" Chem. Biol. 1998, 5, R277-R283. [Article Link]

41. Michael, K.; Tor. Y. "Designing Novel RNA Binders" Chem. Eur. J. 1998, 4, 2091-2098. [Article Link]

40. Hurley, D. J.; Tor, Y. "Metal-Containing Oligonucleotides: Solid-Phase Synthesis and Luminescence Properties" J. Am. Chem. Soc. 1998, 120, 2194-2195. [Article Link]

39. Connors, P. J.; Tazlis, D.; Dunnick, A. L.; Tor, Y. "Coordination Compounds as Building Blocks: Single-Step Synthesis of Heteronuclear Multimetallic Complexes Containing Ru(II) and Os(II)" Inorg. Chem. 1998, 37, 1121-1123. [Article Link]

38. Kirk, S. R.; Tor, Y. "Hydrolysis of an RNA Dinucleoside Monophosphate by Neomycin B" Chem. Commun. 1998,147-148. [Article Link]

37. Thomas, C. W.; Tor. Y. "Dendrimers and Chirality" Chirality 1998, 10, 53-59. Angew. Chem. Int. Ed. 1998, 37, 109-111. [Article Link]

36 Wang, H.; Tor. Y. "RNA Aminoglycoside Interactions: The Design, Synthesis and Binding of "Amino-Aminoglycosides" to RNA" Angew. Chem. Int. Ed. 1998, 37, 109-111. [Article Link]

35. Tzalis, D.; Tor, Y. "The Organic Chemistry of Coordination Compounds: Unprecedented Substitution Reactions of Functionalized Polypyridine Complexes" Angew. Chem. Int. Ed. 1997, 36, 2666-2668. [Article Link]

34. Wang, H.; Tor. Y. "Electrostatic Interactions in RNA-Aminoglycosides Binding" J. Am. Chem. Soc. 1997, 119,8734-8735. [Article Link]

33. Wang, H.; Tor. Y. "Dimeric Aminoglycosides: Design, Synthesis and RNA Binding" Bioorg. Med. Chem. Lett. 1997,7, 1951-1956. [Article Link]

32. Tazlis, D.; Tor, Y. "Stereochemically-Defined Supramolecular Architectures: Diastereomerically-Pure Mutli-Ru(II) Complexes" J. Am. Chem. Soc. 1997, 119, 852-853. [Article Link]

31. Tzalis, D.; Tor. Y. "Toward Self-Assembling Dendrimers: Metal Complexation Induces the Assembly of Hyperbranched Structures" Tetrahedron Lett. 1996, 37, 8293-8296. [Article Link]

30. Tzalis, D.; Tor. Y. "Coordination Compounds as Building Blocks: Single-Step Synthesis of Multi-Ru(II) Complexes" Chem. Commun. 1996, 1043-1044. [Article Link]

29. Nicolaou, K. C.; Smith, B. M.; Ajito, K.; Komatsu, H.; Gomez-Paloma, L.; Tor, Y. "DNA-Carbohyrate Interactions. Specific Binding of Head-to-Head and Head-to-Tail Dimers of the Calicheamicin Oligosaccharide to Duplex DNA" J. Am. Chem. Soc. 1996, 118, 2303-2304. [Article Link]

28. Tzalis, D.; Tor, Y. "Tuning the Electronic Properties of Phenanthroline Ligands: 3,8-Bis(arylethynyl)-1,10-Phenanthrolines and their Ru(II) Complexes" Tetrahedron Lett. 1995, 36, 6017-6020. [Article Link]

27. Tzalis, D.; Tor, Y.; Failla, S.; Siegel, J. S. "Simple One-Step Synthesis of 3-Bromo- and 3,8-Dibromo-1,10-Phenanthroline: Fundamental Building Blocks in the Design of Metal Chelates" Tetrahedron Lett. 1995, 36, 3489-3490. [Article Link]

26. Tor, Y. "Dendritic Polyphosphates: Globular Polyelectrolytes?" in Supramolecular Stereochemistry, Siegel, J. S. Ed.; Springer Netherlands, 1995, pp. 247-253. [Chapter Link]

25. Steinberg, S.; Tor Y.; Rubinstein, I. "Ion-Selective Monolayer Membranes Based upon Self-Assembly Tetradentate Ligand Monolayers on Gold Electrodes: Nature of the Ionic Selectivity" Thin Films 1995, 20, 183-205. [Article Link]

24. Tor, Y. Dervan, P. B. "Site-Specific Enzymatic Incorporation of an Unnatural Base, N6-(6-Aminohexyl)isoguanosine, into RNA" J. Am. Chem. Soc. 1993, 115, 4461-4467. [Article Link]

23. Libman, J.; Tor Y.; Dayan, I.; Shanzer, A.; Lifson, S. "Synthetic Receptors Possessing Non-Covalent Macrocyclic Rings" Isr. J. Chem. 1992, 32, 31-40. [Article Link]

22. Dayan, I.; Tor, Y.; Libman, J.; Shanzer, A. "Li+ and Ca+2 Ions as Complementary Regulatory Elements for the Formation of Propeller-like Conformations" J. Org. Chem. 1992, 57, 6060-6063. [Article Link]

21. Tor, Y.; Libman, J.; Shanzer, A.; Felder, C. E.; Lifson, S. "Chiral Siderophore Analogs: Enterobactin" J. Am. Chem. Soc. 1992, 114, 6661-6671. [Article Link]

20. Tor, Y.; Libman, J.; Shanzer, A.; Felder, C. E.; Lifson, S. "Tripodal Peptides with Chiral Conformations Stabilized by Interstrand Hydrogen Bonds" J. Am. Chem. Soc. 1992, 114, 6653-6661. [Article Link]

19. Paterlini, M. G.; Freedman, T. B.; Nafie, L. A.; Tor, Y.; Shanzer, A. "Vibrational Circular Dichroism of Interchain Hydrogen-Bonded Tripodal Peptides" Biopolymers 1992, 32, 765-782. [Article Link]

18. Steinberg, S.; Tor, Y.; Sabatani, E.; Rubinstein, I. "Ion-Selective Monolayer Membranes Based upon Self-Assembly Tetradentate Ligand Monolayers on Gold Electrodes. 2. The Effect of Applied Potential on the Ion Binding" J. Am. Chem. Soc. 1991,113, 5176-5182. [Article Link]

17. Goldfarb, D.; Fauth, J.-M.; Tor, Y.; Shanzer, A. "Study of Cu(II) Binding to Novel Chiral Tripodal Ligands by Electron Spin Echo Spectroscopy" J. Am. Chem. Soc. 1991, 113, 1941-1948. [Article Link]

16.Shanzer, A.; Yakirevitch, P.; Gottlieb, H.; Tor, Y.; Libman, J. "Polytopic Chiral Binders" Pure Appl. Chem. 1990, 62, 1111-1114. [Article Link]

15. Tor, Y.; Shanzer, A.; Scherz, A. "Geometries of Non-Transition-Metal Complexes of a Novel Chiral b-Keto Amide Tripodal Ligand Elucidated from Optical Transitions to Excitonic States" Inorg. Chem. 1990, 29, 4096-4099. [Article Link]

14. Lifson, S.; Tor, Y.; Libman, J.; Shanzer, A. "Biomimetic Design on Ion-Carriers" Pept.: Chem., Struct. Biol., Proc. Am. Pept. Symp.,11th 1990, 795-797.

13. Shanzer, A.; Libman, J.; Lazar, R.; Tor, Y. "Receptor Mapping with Artifical Siderophores" Pure Appl. Chem. 1989, 61, 1529-1534. [Article Link]

12. Feinstein-Jaffe, I.; Boazi, M.; Tor, Y. "Assessment of the Purity of D,L HM-PAO from Diasteroemtric Mixtures Using NMR Techniques" J. Nuc. Med. 1989, 30, 106-109. [Article Link]

11. Shanzer, A.; Libman, J.; Lazar, R.; Tor, Y.; Emery, T. "Synthetic Ferrichrome Analogues with Growth Promotion Activity for Arthrobacter Flavescens" Biochem. Biophys. Res. Comm. 1988, 157, 389-394. [Article Link]

10. Rubinstein, I.; Steinberg, S.; Tor Y.; Shanzer, A.; Sagiv J. "Ionic Recognition and Selective Response in Self-Assembling Monolayer Membrane on Electrodes" Nature 1988, 332, 426-429. [Article Link]

9. Libman, J.; Tor, Y.; Shanzer, A. "From Ring Structures to Helices" J. Coord. Chem. 1988, 18, 241-244. [Article Link]

8. Shanzer, A.; Libman, J.; Tor Y.; Gottlieb, H. "Helical Structures: Artificial Solutions for Ion Transport" in Transport through Membranes: Carriers, Channels and Pumps; Pullman, A.; Jortner, J.; Pullman, B. Ed.; Springer Netherlands, 1988; pp. 57-66. [Chapter Link]

7. Tor, Y.; Libman, J.; Shanzer, A. "Biomimetic Ferric Ion Carriers. Chiral Ferrichrome Analogs" J. Am. Chem. Soc. 1987, 109, 6518-6519. [Article Link]

6. Tor, Y.; Libman, J.; Shanzer, A.; Lifson, S. "Biomimetic Ferric Iion Carriers. A Chiral Analog of Enterobactin" J. Am. Chem. Soc. 1987, 109, 6517-6518. [Article Link]

5. Libman, J.; Tor, Y.; Shanzer, A. "Helical Ferric Ion Binders" J. Am. Chem. Soc. 1987, 109, 5880-5881. [Article Link]

4. Tor, Y.; Libman, J.; Shanzer, A.; Felder, C. E.; Lifson, S. "A Trispeptide Circularly Organized through Inter-chain Hydrogen Bonds" J. Chem. Soc. Chem. Commun. 1987, 749-750. [Article Link]

3. Tor, Y.; Libman, J.; Lazar, R.; Frolow, F.; Gottlieb, H. E.; Shanzer, A. "Template Synthesis, Structure and Binding Properties of Marcocyclic Oxa-Thialactones" J. Org. Chem. 1985, 50, 5476-5480. [Article Link]

2. Lerman, O.; Tor, Y.; Habel, D.; Rozen, S. "A Novel Electrophilic Fluorination of Activated Aromatic Rings Using Acetyl Hypofluorite Suitable also for Introduction of 18F into Benzene Nuclei", J. Org. Chem. 1984, 49, 806-813. [Article Link]

1. Lerman, O.; Tor, Y.; Rozen, S. "Acetyl Hypofluorite as a Taming Carrier of Elemental Fluorine for Novel Electrophilic Fluorination of Activated Aromatic Rings", J. Org. Chem. 1981, 46, 4629-4631. [Article Link]

Contact Professor Tor

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    Pacific Hall 6225A (Tor Office)
    Pacific Hall 6227 - 6228 - 6127